Genetic polymorphisms of the renin-angiotensin-aldosterone system and renal insufficiency in essential hypertension.

摘要: Objective The renin-angiotensin-aldosterone system (RAAS) plays an important role in the control of renal function both physiological and pathological conditions. aim present study was to evaluate relation between four genetic polymorphisms RAAS insufficiency a population patients with essential hypertension living north-east Italy. Design methods Eighty-six hypertensive 172 without damage matched for age duration within 2 years were evaluated. Genotyping insertion/ deletion angiotensin-converting enzyme (ACE I/D), angiotensinogen (AGT) M235T, angiotensin II type 1 receptor (AT R) A1166C aldosterone synthase (CYP11 B2) -344C/T performed using polymerase chain reaction, further restriction analysis when required. Results Each genes associated failure; adjusted odds ratios 1.47 1.89 ACE D allele, assuming co dominant recessive mode inheritance, respectively; 1.51 AGT T235 allele dominant, 1.98 recessive, pattern inheritance; 1.79 AT R C1166 considering pattern; 3.89 CYP11B2 -344C as effect. However, genotypes not Hardy-Weinberg equilibrium among controls. associations TT-AT AC CC-ACE DD showed possible positive interaction development subjects. association MM-AT AA AA-CYP11B2 TT or TC combinations reduced risk failure. Conclusions Our findings suggest that unfavorable may contribute increased