Angiotensin I-converting enzyme gene insertion/deletion and angiotensinogen M235T polymorphisms: Risk of chronic renal failure

摘要: Angiotensin I-converting enzyme gene insertion/deletion and angiotensinogen M235T polymorphisms: Risk of chronic renal failure. Background Chronic failure (CRF) is a complex phenotype that results from an underlying kidney disease superimposing environmental genetic factors. The aim our study was to evaluate the role polymorphisms in genes encoding for components renin-angiotensin system (RAS) development and/or progression CRF. Methods Two hundred forty-seven family trios (patients with CRF both parents; 120 primary glomerulonephritis, 80 interstitial nephritis, 47 type 1 diabetes nephropathy) were examined, transmission/disequilibrium test (TDT) used allele transmission heterozygous parents affected offspring. Results D angiotensin (ACE) polymorphism transmitted significantly more frequently than expected no association among all examined subgroup patients nephritis. 235T association, but effect seen only presence DD or ID genotype associated faster rate decline function, which not observed polymorphism. For chymase II receptor gene, did deviate random proportion 50:50%. Conclusions this suggest ACE contribute increased risk CRF, magnitude within subsets specific etiologies must be evaluated further.