A scalable and modular lab-on-a-chip genetic analysis instrument
作者： G. V. Kaigala , M. Behnam , A. C. E. Bidulock , C. Bargen , R. W. Johnstone
DOI: 10.1039/B925111A
关键词: Orders of magnitude (temperature) 、 Sensitivity (control systems) 、 Instrumentation (computer programming) 、 Scalability 、 Modular design 、 Computer science 、 Lab-on-a-chip 、 Component (UML) 、 Embedded system 、 System on a chip
摘要: We demonstrate a new and extremely inexpensive, multipurpose desktop system for operating lab-on-a-chip (LOC) devices. The provides all of the infrastructure necessary genetic amplification analysis, with orders magnitude improvement in performance over our previous work. A modular design enables high levels integration while allowing scalability to lower cost smaller size. component this is ca. $600, yet it could support many diagnostic applications. an implementation via polymerase chain reaction (PCR), analysis using capillary electrophoresis (CE). PCR able amplify from single or several copies target DNA CE (e.g. sensitivity) comparable that commercial photomultiplier-based confocal lab-on-chip instrumentation. believe demonstrates need no longer be barrier wide-spread application LOC technologies healthcare beyond.
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