Drug delivery and cell interaction of adhesive poly(ethyleneimine)/sulfated polysaccharide complex particle films
作者： Martin Müller , Bernhard Torger , Diana Wehrum , David Vehlow , Birgit Urban
DOI: 10.1116/1.4913195
关键词: Polymer chemistry 、 Nanoparticle 、 Fourier transform infrared spectroscopy 、 Ethyleneimine 、 Substrate (chemistry) 、 Chemical engineering 、 Drug delivery 、 Materials science 、 Polyelectrolyte 、 Dynamic light scattering 、 Colloid
摘要: Herein, the authors report and review polyelectrolyte complex (PEC) nanoparticles (NPs) loaded with zoledronate (ZOL) simvastatin their effects on bone cells. PEC NPs are intended for modification of substitute materials. For characterization, they can be solution casted germanium (Ge) substrates serving as analytically accessible model substrate. were generated by mixing poly(ethyleneimine) (PEI) either linear cellulose sulfate (CS) or branched dextransulfate (DS). Four important requirements drug films addressed herein, which colloidal stability dispersions (1), interfacial (2), cytocompatibility (3), retarded release (4). Dynamic light scattering measurements (DLS) showed that both PEI/CS PEI/DS NP obtained hydrodynamic radii in range 35–170 nm colloidally stable up to several months. Transmission FTIR spectroscopy evidenced systems con...
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