Serving the new masters – dendritic cells as hosts for stealth intracellular bacteria

摘要: Summary Dendritic cells (DCs) serve as the primers of adaptive immunity, which is indispensable for control majority infections. Interestingly, some pathogenic intracellular bacteria can subvert DC function and gain advantage an ineffective host immune reaction. This scenario appears to be case particularly with so-called stealth pathogens, are causative agents several under-diagnosed chronic diseases. However, there no consensus how less explored like Coxiella, Brucella Francisella cross-talk DCs. Therefore, aim this review was explore issue summarize current knowledge regarding interaction above mentioned pathogens DCs crucial hosts from infection strategy view. Evidence indicates that infected not sufficiently activated, do undergo maturation produce expected proinflammatory cytokines. In cases, even display immunosuppressive behaviour may directly linked induction tolerogenicity favouring pathogen survival persistence.