Mycobacterium tuberculosis and dendritic cells: recognition, activation and functional implications.

摘要: The highly complex nature of interactions Mycobacterium tuberculosis with cells the immune system has puzzled researchers world-over in understanding pathogenesis and immunology associated (TB). This contributed to delay development effective vaccine(s) for TB. Several excellent studies have provided only a glimpse kind degree responses elicited following infection by mycobacteria. Preferred entry via respiratory route results capture mycobacteria alveolar macrophages that eventually become their long-term hosts. Since pathogen is rarely cleared this resulted human population serving as large reservoir Owing unique ability prime naive memory T cells, dendritic (DCs) play important indispensable roles initiation maintenance protective infection. response initiated DCs respect determines character mounted host against pathogen. profile cytokines chemokines secreted result further plays an role defining course minireview attempts highlight key cells. We discus uptake followed DC activation spectrum infected/activated DCs, numerous ways devised subvert responses.