Role of M. tuberculosis RD-1 region encoded secretory proteins in protective response and virulence

摘要: A gene fragment corresponding to the region of difference-1 (RD-1) Mycobacterium tuberculosis genome, spanning open reading frames Rv3871 Rv3879c, is missing in all bacillus Calmette-Guerin (BCG) vaccine strains M. bovis, indicating that this was perhaps primary deletion event responsible for attenuation virulent bovis. The RD-1 locus has, therefore, been considered crucial pathogenesis tuberculosis. Two most predominant secretory proteins encoded by viz. CFP-10 (Rv3874) and ESAT-6 (Rv3875) are being widely evaluated as candidate vaccine(s) used antigens diagnosis However, several recent reports have implicated their putative role deactivation macrophage dendritic cell functions. large body literature provides an inkling various mechanisms these might use down regulate normal functions possible contribution virulence This review re-emphasizes suggestion about dual function two secreted mycobacterial proteins, viz., they both T-cell activation