A tuberculosis tb vaccine to prevent reactivation

作者: Carina Vingsbo Lundberg , Peter Andersen , Truc Thi Kim Than Hoang , Jes Dietrich

DOI:

关键词: VirologyTuberculosisBiologyLatent tuberculosisMicrobiologyMycobacterium tuberculosisGene

摘要: The present invention discloses a vaccine or immunogenic composition that can be administred to latently infected individuals prevent reactivation of latent tuberculosis infection caused by species the complex microorganisms (Mycobacterium tuberculosis., M.bovis, M.africanum), is base on number M. derived proteins and protein fragments which are constitutively expressed in different stages infection. directed use these polypeptides, immunologically active thereof genes encoding them for immunological compositions such as vaccines.

参考文章(71)
Rikke Louise Vinther Skjot, Karin Weldingh, Christina Veggerby Hansen, Peter Andersen, Li Mei Meng Okkels, Peter Birk Rasmussen, Walter Florio, TB diagnostic based on antigens from M. tuberculosis ,(2007)
Pascal Mettens, James Brown, Dennis Murphy, Novel compositions and methods ,(2009)
Kristi M. Guinn, Mark J. Hickey, Sanjeev K. Mathur, Kelly L. Zakel, Jeff E. Grotzke, David M. Lewinsohn, Sherilyn Smith, David R. Sherman, Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis Molecular Microbiology. ,vol. 51, pp. 359- 370 ,(2004) , 10.1046/J.1365-2958.2003.03844.X
Ida Rosenkrands, Anette Stryhn, Peter Andersen, Therapeutic TB vaccine ,(2003)
Laleh Majlessi, Caroline Demangel, Claude Leclerc, Priscille Brodin, Roland Brosch, Stewart Cole, Alexander S. Pym, Identification of virulence associated regions RD1 and RD5 leading to improve vaccine of M. bovis BCG and M. microti ,(2003)
Douglas B Lowrie, Ricardo E Tascon, Vania LD Bonato, Valeria MF Lima, Lucia H Faccioli, Evangelos Stavropoulos, M Joseph Colston, Robert G Hewinson, Karin Moelling, Celio L Silva, None, Therapy of tuberculosis in mice by DNA vaccination. Nature. ,vol. 400, pp. 269- 271 ,(1999) , 10.1038/22326