Sigma-1 receptor is involved in degradation of intranuclear inclusions in a cellular model of Huntington's disease
作者： Yasuo Miki , Kunikazu Tanji , Fumiaki Mori , Koichi Wakabayashi
DOI: 10.1016/J.NBD.2014.11.005
关键词: Epoxomicin 、 Huntingtin 、 Proteasome 、 Endoplasmic reticulum 、 Biology 、 Molecular biology 、 Transfection 、 Endoplasmic-reticulum-associated protein degradation 、 Inclusion bodies 、 Cytoplasm
摘要: … The anti-SIGMAR1 antibody immunostained most of the small intranuclear mutant huntingtin aggregates (Figs. 1B,C). Some of the SIGMAR1-immunopositive nuclear inclusions were …
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