HLA-G is expressed in intestinal samples of ulcerative colitis and Crohn’s disease patients and HLA-G5 expression is differentially correlated with TNF and IL-10 cytokine expression
作者： Eduardo Antônio Donadi , Norma Lucena-Silva , Renan Garcia Gomes , Carlos Alexandre Antunes de Brito , Valéria Ferreira Martinelli
DOI: 10.1016/J.HUMIMM.2018.03.006
关键词: Ulcerative colitis 、 Immunology 、 Tumor necrosis factor alpha 、 Interleukin 10 、 Crohn's disease 、 Inflammation 、 Inflammatory bowel disease 、 HLA-G 、 Colitis 、 Medicine 、 Immunology and Allergy 、 General Medicine
摘要: HLA-G is an immunomodulatory molecule that can be produced by epithelial cells. Considering TNF and IL-10 participate in bowel inflammatory disorders both cytokines modulate HLA-G, we evaluated mRNA expression qPCR protein levels immunohistochemistry two intestinal samples exhibiting different degree of inflammation within a patient suffering from Crohn's disease (CD) or ulcerative colitis (UC). Tissue HLA-G5 (P < 0.0001), = 0.0004) 0.0169) were higher areas intense compared to low inflammation, not associated with mucosal inflammation. In CD, the was correlated inflamed areas, TNF:IL-10 ratio 3, but increased 9-folds. UC, IL-10, irrespective grade, little variation various areas. mild Both CD UC exhibited gene HLA-G; differentially depending on type underlying disorder.
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