作者: Marco Cantini , Cristina González-García , Virginia Llopis-Hernández , Manuel Salmerón-Sánchez
DOI: 10.1021/BK-2012-1120.CH022
关键词: Cellular differentiation 、 Network structure 、 Fibronectin 、 Extracellular matrix organization 、 Adhesion 、 Fibrillogenesis 、 Cell biology 、 Fibril 、 Materials science
摘要: Material-driven fibronectin fibrillogenesis is a novel route to engineer the network structure and biological activity of fibrillar matrices in analogy with their physiological cell-mediated assembly. We identify specific surface chemistries that promote cell-free formation physiological-like fibrils time- concentration-dependent process. Our most recent relevant results, reviewed chapter, demonstrate role this material-induced cell adhesion, extracellular matrix organization degradation, differentiation.