Moderate selenium dosing inhibited chromium (VI) toxicity in chicken liver
作者： Yang Wang , Yongxia Liu , Huiyu Wan , Yiran Zhu , Peng Chen
DOI: 10.1002/JBT.21916
关键词: ATPase 、 Superoxide dismutase 、 Oxidative stress 、 Endocrinology 、 Toxicology 、 Internal medicine 、 Malondialdehyde 、 Chemistry 、 Selenium 、 Glutathione 、 Chromium 、 Toxicity
摘要: This study aimed to clarify the effect of selenium (Se) on chromium (VI) [Cr(VI)]-induced damage in chicken liver. A total 105 chickens were randomly divided into seven groups 15. Group I received deionized water; group II Cr(VI) (7.83 mg/kg/d) alone; and other orally both Se different doses (0.14, 0.29, 0.57, 1.14, 2.28 mg/kg/d). The levels superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), Ca2+ -ATPase, mitochondrial membrane potential (MMP) measured. Results showed that increased MDA content decreased GSH content, T-SOD activity, -ATPase MMP level. Meanwhile, co-treatment 0.57 viability above indicators compared with Cr(VI)-treatment alone. In addition, histopathologic examination revealed can cause liver damage, whereas supplementation moderate dose inhibited this damage. confirmed exerted protective against Cr(VI)-induced
sci-hub.se 参考文章(52)
Alena Viktorinova, Monika Ursinyova, Jana Trebaticka, Iveta Uhnakova, Zdenka Durackova, Vlasta Masanova, Changed Plasma Levels of Zinc and Copper to Zinc Ratio and Their Possible Associations with Parent- and Teacher-Rated Symptoms in Children with Attention-Deficit Hyperactivity Disorder. Biological Trace Element Research. ,vol. 169, pp. 1- 7 ,(2016) , 10.1007/S12011-015-0395-3
Tong Xu, Xuejiao Gao, Guowen Liu, The Antagonistic Effect of Selenium on Lead Toxicity Is Related to the Ion Profile in Chicken Liver Biological Trace Element Research. ,vol. 169, pp. 365- 373 ,(2016) , 10.1007/S12011-015-0422-4
Ezdihar Hassoun, Lennart Dencker, Bengt R. G. Danielsson, Embryotoxicity of chromium: Distribution in pregnant mice and effects on embryonic cells in vitro Archives of Toxicology. ,vol. 51, pp. 233- 245 ,(1982) , 10.1007/BF00348855
Ke Jian Liu, Xianglin Shi, In vivo reduction of chromium (VI) and its related free radical generation Molecular Mechanisms of Metal Toxicity and Carcinogenesis. ,vol. 222, pp. 41- 47 ,(2001) , 10.1007/978-1-4615-0793-2_6
Jun-Ru Hu, Yan-Hua Huang, Guo-Xia Wang, Ying-Xia Wu, Jian-An Xian, An-Li Wang, Jun-Ming Cao, Deficient and excess dietary selenium levels affect growth performance, blood cells apoptosis and liver HSP70 expression in juvenile yellow catfish Pelteobagrus fulvidraco. Fish Physiology and Biochemistry. ,vol. 42, pp. 249- 261 ,(2016) , 10.1007/S10695-015-0133-Y
Chunpeng Liu, Jing Fu, Ci Liu, Shu Li, The role of nitric oxide and autophagy in liver injuries induced by selenium deficiency in chickens RSC Advances. ,vol. 5, pp. 50549- 50556 ,(2015) , 10.1039/C5RA01030F
Roderick C. McKenzie, John R. Arthur, Geoffrey J. Beckett, Selenium and the Regulation of Cell Signaling, Growth, and Survival: Molecular and Mechanistic Aspects Antioxidants & Redox Signaling. ,vol. 4, pp. 339- 351 ,(2002) , 10.1089/152308602753666398
Mokhtar I Yousef, Fatma M El-Demerdash, Kamil I Kamil, Fathia AM Elaswad, None, Ameliorating effect of folic acid on chromium(VI)-induced changes in reproductive performance and seminal plasma biochemistry in male rabbits Reproductive Toxicology. ,vol. 21, pp. 322- 328 ,(2006) , 10.1016/J.REPROTOX.2005.09.005
Young Jae Choi, Na Na Kim, Hyun Suk Shin, Mi Seon Park, Gyung-Suk Kil, Cheol Young Choi, Effects of waterborne selenium exposure on the antioxidant and immunological activity in the goldfish, Carassius auratus Molecular & Cellular Toxicology. ,vol. 9, pp. 365- 373 ,(2013) , 10.1007/S13273-013-0045-9
Elzbieta Kalisinska, Jerzy Gorecki, Anna Okonska, Bogumila Pilarczyk, Agnieszka Tomza-Marciniak, Halina Budis, Natalia Lanocha, Danuta I. Kosik-Bogacka, Katarzyna M. Kavetska, Mariusz Macherzynski, Janusz M. Golas, Mercury and selenium in the muscle of piscivorous common mergansers (Mergus merganser) from a selenium-deficient European country. Ecotoxicology and Environmental Safety. ,vol. 101, pp. 107- 115 ,(2014) , 10.1016/J.ECOENV.2013.12.019