Shaping of interphase chromosomes by the microtubule network

摘要: It is well established that microtubule dynamics play a major role in chromosome condensation and localization during mitosis. During interphase, however, it assumed the metazoan nuclear envelope presents physical barrier, which inhibits interaction between microtubules located cytoplasm chromatin fibers nucleus. In recent years, has become apparent alter structure function interphase as well. Microtubule motor proteins transport several transcription factors exogenous DNA (such plasmid DNA) from to Various soluble components are able translocate into nucleus, where they bind various elements leading transcriptional alterations. addition, may apply force on envelope, transmitted changes structure. Thus, affect spatial organization, transcription, replication repair.