APC and β-Catenin Degradation

摘要: The adenomatous polyposis coli (APC) gene encodes a tumor suppressor that is mutated in familial (FAP) colon cancer as well the large majority of sporadic colorectal cancers (reviewed ref 1, Chapter by Sansom, Kwong and Dove). Most mutations APC associated with increased incidence generate truncated form APC.2, 3 While many studies have implicated protein regulation cytoskeleton 4, Morrison, Caldwell Kaplan et al. ), there also compelling evidence key component Wnt/β-catenin signaling refs. 3, 5). Consistent this, loss APC1 APC2 genes Drosophila result elevated signaling.6–8 Mutations mice or zebrafish increase susceptibility these animals to developing elevation tumors.9,10 In this chapter, we will focus on role negative regulator pathway.