Lipid phosphatases as drug discovery targets for type 2 diabetes

摘要: The soaring incidence of type 2 diabetes has created pressure for new pharmaceutical strategies to treat this devastating disease. With much the focus on overcoming insulin resistance, investigation focused finding ways restore activation phosphatidylinositol 3'-kinase pathway, which is diminished in many patients with diabetes. Here we review evidence that lipid phosphatases, specifically PTEN and SHIP2, attenuate important signalling pathway. Both vivo vitro studies indicate their role regulating whole-body energy metabolism, possibly weight gain as well. promise challenges presented by class drug discovery targets will also be discussed.