THE EFFECT OF INSULIN ON EXPRESSION OF GENES AND BIOCHEMICAL PATHWAYS IN HUMAN SKELETAL MUSCLE

摘要: Diabetes is one of the metabolic diseases which have reached to proportions epidemic. The number individuals suffering from diabetes around 150 million worldwide will double in next 20 years. According WHO data for diabetes, there are 346 people affected with worldwide, and by end year 2004 around. 3.4 diabetic individual died, this deaths according projections be between 2005 2030. classified into various types but two major forms Type 1 (Autoimmune disease caused destruction insulin producing beta cells pancreas) 2 (caused impairment production cells). In paper we discuss mainly about Insulin action on gene expression. Various in-vivo studies shown that skeletal muscles site dependent glucose disposal also know type resistance main feature. primary defect development not known been recognized an early pathogenesis diabetes.