Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17

摘要: Correct glutamate receptor localization in neurons is crucial for neurotransmission the brain. Here we investigated mechanisms underlying of kainate GluR5 receptors to dendrites cultured hippocampal neurons. We find that distribution depends on association with GluR6 and KA2 subunits. The subunit was expressed distal only when subunits were present, whereas it restricted proximal absence these overlap between organization microtubules led us examine whether KIF17, a microtubule motor protein dendrites, involved dendrites. show here, first time KIF17 interacts required defining novel mechanism controls