Compartmentalization of TNF Receptor 1 Signaling: Internalized TNF Receptosomes as Death Signaling Vesicles
作者： Wulf Schneider-Brachert , Vladimir Tchikov , Jens Neumeyer , Marten Jakob , Supandi Winoto-Morbach
DOI: 10.1016/J.IMMUNI.2004.08.017
关键词: Endocytosis 、 Signal transduction 、 Endosome 、 FADD 、 Tumor Necrosis Factor Decoy Receptors 、 Endocytic vesicle 、 Internalization 、 Biology 、 Cell biology 、 TRADD
摘要: The molecular regulation of the recruitment initial signaling complexes at TNF-R1 is poorly defined. We demonstrate here that within minutes internalized (TNF receptosomes) recruits TRADD, FADD, and caspase-8 to establish "death-inducing complex" (DISC). In addition, we identified internalization domain (TRID) required for receptor endocytosis provide evidence internalization, DISC formation, apoptosis are inseparable events. Analyzing cell lines expressing an internalization-deficient (TNF-R1 DeltaTRID) revealed RIP-1 TRAF-2 occurred level plasma membrane. contrast, aggregation TNF-R1-associated critically dependent on endocytosis. Furthermore, fusion TNF receptosomes with trans-Golgi vesicles results in activation acid sphingomyelinase cathepsin D. Thus, different pathways by compartmentalization membrane-derived endocytic harboring DISC.
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sci-hub.se 参考文章(32)
Peter H. Krammer, CD95's deadly mission in the immune system Nature. ,vol. 407, pp. 789- 795 ,(2000) , 10.1038/35037728
J. M. D. Coey, Magnetism and Magnetic Materials Magnetism and Magnetic Materials. ,(2001) , 10.1017/CBO9780511845000
F. C. Kischkel, S. Hellbardt, I. Behrmann, M. Germer, M. Pawlita, P. H. Krammer, M. E. Peter, Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. The EMBO Journal. ,vol. 14, pp. 5579- 5588 ,(1995) , 10.1002/J.1460-2075.1995.TB00245.X
H Wajant, K Pfizenmaier, P Scheurich, Tumor necrosis factor signaling. Cell Death & Differentiation. ,vol. 10, pp. 45- 65 ,(2003) , 10.1038/SJ.CDD.4401189
V. Tchikov, S. Winoto-Morbach, D. Kabelitz, M. Krönke, S. Schütze, Adhesion of immunomagnetic particles targeted to antigens and cytokine receptors on tumor cells determined by magnetophoresis Journal of Magnetism and Magnetic Materials. ,vol. 225, pp. 285- 293 ,(2001) , 10.1016/S0304-8853(00)01252-X
Bryan C Barnhart, Marcus E Peter, The TNF Receptor 1: A Split Personality Complex Cell. ,vol. 114, pp. 148- 150 ,(2003) , 10.1016/S0092-8674(03)00561-0
Dieter Adam, Katja Wiegmann, Sabine Adam-Klages, Andrea Ruff, Martin Krönke, A Novel Cytoplasmic Domain of the p55 Tumor Necrosis Factor Receptor Initiates the Neutral Sphingomyelinase Pathway Journal of Biological Chemistry. ,vol. 271, pp. 14617- 14622 ,(1996) , 10.1074/JBC.271.24.14617
Tudor M Baetu, John Hiscott, On the TRAIL to apoptosis Cytokine & Growth Factor Reviews. ,vol. 13, pp. 199- 207 ,(2002) , 10.1016/S1359-6101(02)00006-0
Martin R Sprick, Markus A Weigand, Eva Rieser, Charles T Rauch, Peter Juo, John Blenis, Peter H Krammer, Henning Walczak, FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2 Immunity. ,vol. 12, pp. 599- 609 ,(2000) , 10.1016/S1074-7613(00)80211-3
Pier Paolo Di Fiore, Pietro De Camilli, Endocytosis and Signaling: An Inseparable Partnership Cell. ,vol. 106, pp. 1- 4 ,(2001) , 10.1016/S0092-8674(01)00428-7