Analysis of serum α-fetoprotein-L3% and des-γ carboxyprothrombin markers in cases with misleading hepatocellular carcinoma total α-fetoprotein levels

摘要: Serum fraction of α-fetoprotein L3 (AFP-L3%) and des-γ carboxyprothrombin (DCP) are proposed serum markers for the diagnosis hepatocellular carcinoma (HCC). We evaluated their performance in two patient populations with total AFP levels non-diagnostic HCC. From a cohort 150 consecutive patients HCC, 60 <200 ng/ml were identified. Additionally, 50 elevated no radiological evidence at least one year follow-up, included. AFP-L3% DCP measured by Liquid Phase Binding Assay System (LiBASys). In cases where was undetectable, more sensitive method based on-chip electrokinetic reaction applied. found to be positive 22 (36.7%) HCC 6 (12%) non-HCC patients. 26 (43%) none Thirty-six out sixty (60%) either or DCP. With technology, 10 5 without who tested negative LiBASys. The final sensitivity combined AFP, testing, entire 84%. specificity studied population 78.5 100%, respectively. addition increased on chip assay but less specific compared