Current Advances in Antitubercular Drug Discovery: Potent Prototypes and New Targets
作者： Guilherme Felipe dos Santos Fernandes , Paula Hartmann Jornada , Carolina de Souza , Chung Man Chin , Fernando Rogerio Pavan
DOI: 10.2174/0929867322666150818103836
关键词: Infectious disease (medical specialty) 、 Mycobacterium 、 Computational biology 、 Latent tuberculosis 、 Mycobacterium tuberculosis 、 World health 、 Biology 、 Drug discovery 、 Low toxicity 、 Tuberculosis 、 Immunology
摘要: Tuberculosis (TB) is an infectious disease caused by bacterium of the Mycobacterium genus, mainly tuberculosis (MTB). The World Health Organization aims to substantially reduce number cases in coming years; however, increased multidrug-resistant (MDR) and extremely drug-resistant (XDR) forms lack treatment for latent are challenges be overcome. In this review, we have identified most potent compounds described literature during recent years with MIC values < 7 µM, low toxicity a high selective index. addition, emerging targets MTB presented provide new perspectives discovery antitubercular drugs. This review summarize current advances promote insights into drug discovery.
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