Progestin Receptors in the Anterior Pituitary and Hypothalamus of Male Rats
作者： Oddvar Naess , Arne Attramadal
DOI: 10.1111/J.1365-2605.1978.TB00016.X
关键词: Chemistry 、 Progestin 、 Cyproterone acetate 、 Internal medicine 、 Anterior pituitary 、 Dissociation constant 、 Endocrinology 、 Cytosol 、 Hypothalamus 、 Testosterone 、 Receptor
摘要: Properties of progestin receptors in the pituitary and hypothalamic cytosol fraction male rats were studied using highly potent (3H) R 5020 (17,20-dimethyl-19-nor-pregna-4,9-diene-3,20-dione). As shown by sucrose gradient analysis, specific binding is associated with components migrating at 7 S 4 S. The isoelectric point 5.8. since it easily displaced unlabelled progesterone. affinity testosterone, 17β-estradiol cyproterone acetate was much lower, whereas cortisol had no for receptor. dissociation constant approximately 1 times 10-9 M. Pretreatment animals 17β-estradiol-valerate greatly increased receptor levels tissues.
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