Viral replication in patients with concomitant hepatitis B and C virus infections
作者： J. Crespo , J. L. Lozano , B. Carte , B. Heras , F. Cruz
DOI: 10.1007/BF02471908
关键词: Liver disease 、 Biology 、 Hepacivirus 、 Hepatitis B 、 Hepadnaviridae 、 Virology 、 Hepatitis C 、 Hepatitis B virus 、 Hepatitis C virus 、 HBsAg
摘要: The aim of this study was to assess the implications dual infection with hepatitis B virus (HBV) and C (HCV). HBV HCV status in 100 patients chronic analysed. DNA studied using liquid hybridization polymerase chain reaction (PCR). viremia measured qualitative quantitative PCR. genotype determined by Patients were divided into three groups according their HCV-RNA HBsAg status: group I consisted 40 caused HBV; II, HCV; III, 20 infected both viruses. HBV-DNA level higher than III (66.4 vs. 11.5 pg/ml; p < 0.05). Quantification revealed mean values 36.9 copies x 10(5)/ml II 5.5 copies/ml 10(5) (p aminotransferase histological activity III. lb predominant type. data suggest that there is reciprocal inhibition viral replication infection. Liver disease appears be more severe C.
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