Cytotoxicity, cellular accumulation and DNA binding of oxaliplatin isomers
作者： L. Pendyala , Y. Kidani , R. Perez , J. Wilkes , R.J. Bernacki
DOI: 10.1016/0304-3835(95)03974-2
关键词: DNA 、 Cytotoxicity 、 Cell culture 、 Biology 、 Adduct 、 Molecular biology 、 Oxaliplatin 、 Biochemistry 、 Metabolism 、 Biological activity 、 In vitro
摘要: Abstract Oxaliplatin (trans-l-1,2-diaminocyclohexane oxalato Pt(II); 1R,2R-dach, l-OHP), its trans-d isomer (1S,2S-dach) and cis-dach (1R,2S-dach) isomers were compared in vitro testing against human ovarian carcinoma cell lines A2780, A2780/CP (cisplatin resistant), A2780/l-OHP (oxaliplatin colon line HT-29, murine leukemia L1210, L1210/CP L1210/dach (tetraplatin resistant). The relative molar potency of the three complexes all except are trans-l > cis-dach; they = cis-dach. selected for resistance is 3.6-fold resistant to oxaliplatin, showed no 6-fold However, which carboxyphthalato 1,2-dach (trans-dl) platinum(II) 140-fold 73-fold trans-d, 41-fold cis-OHP. accumulation DNA binding platinum following a 2-h treatment A2780 cells with each (60 μM) order corresponded cytotoxicity trans-l, but not others. data suggest that other processes, such as differential formation specific adducts and/or repair may be involved. Of l-OHP superior consistent cytotoxicity.
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sci-hub.se 参考文章(17)
Shigeru Tsukagoshi, Yoshinori Kidani, Kenji Inagaki, Examination of antitumor activities of platinum complexes of 1,2-diaminocyclohexane isomers and their related complexes. GANN Japanese Journal of Cancer Research. ,vol. 67, pp. 921- 922 ,(1976) , 10.20772/CANCERSCI1959.67.6_921
Michaele C. Christian, The current status of new platinum analogs. Seminars in Oncology. ,vol. 19, pp. 720- 733 ,(1992) , 10.5555/URI:PII:0093775492900408
Masahide Noji, Koji Okamoto, Yoshinori Kidani, Tazuko Tashiro, Relation of conformation to antitumor activity of platinum(II) complexes of 1,2-cyclohexanediamine and 2-(aminomethyl)cyclohexylamine isomers against leukemia P388. Journal of Medicinal Chemistry. ,vol. 24, pp. 508- 515 ,(1981) , 10.1021/JM00137A007
L. V. Rubinstein, R. H. Shoemaker, K. D. Paull, R. M. Simon, S. Tosini, P. Skehan, D. A. Scudiero, A. Monks, M. R. Boyd, Comparison of In Vitro Anticancer-Drug-Screening Data Generated With a Tetrazolium Assay Versus a Protein Assay Against a Diverse Panel of Human Tumor Cell Lines Journal of the National Cancer Institute. ,vol. 82, pp. 1113- 1118 ,(1990) , 10.1093/JNCI/82.13.1113
Zahid H. Siddik, Salaam Al-Baker, Timothy L. Burditt, Abdul R. Khokhar, Differential antitumor activity and toxicity of isomeric 1,2-diaminocyclohexane platinum (II) complexes Journal of Cancer Research and Clinical Oncology. ,vol. 120, pp. 12- 16 ,(1993) , 10.1007/BF01200718
G. Mathé, Y. Kidani, M. Segiguchi, M. Eriguchi, G. Fredj, G. Peytavin, J.L. Misset, S. Brienza, F. de Vassals, E. Chenu, C. Bourut, Oxalato-platinum or 1-OHP, a third-generation platinum complex: an experimental and clinical appraisal and preliminary comparison with cis-platinum and carboplatinum Biomedicine & Pharmacotherapy. ,vol. 43, pp. 237- 250 ,(1989) , 10.1016/0753-3322(89)90003-6
T. Tashiro, Y. Kawada, Y. Sakurai, Y. Kidani, Antitumor activity of a new platinum complex, oxalato (trans-l-1,2-diaminocyclohexane)platinum (II): new experimental data. Biomedicine & Pharmacotherapy. ,vol. 43, pp. 251- 260 ,(1989) , 10.1016/0753-3322(89)90004-8
Michael A. Bruck, Robert Bau, Masahide Noji, Kenji Inagaki, Yoshinori Kidani, The crystal structures and absolute configurations of the anti-tumor complexes Pt(oxalato)(1R,2R-cyclohexanediamine) and Pt(malonato)(1R,2R-cyclohexanediamine) Inorganica Chimica Acta. ,vol. 92, pp. 279- 284 ,(1984) , 10.1016/S0020-1693(00)80051-1
Jean Marc Extra, Marc Espie, Fabien Calvo, Christophe Ferme, Laurent Mignot, Michel Marty, Phase I study of oxaliplatin in patients with advanced cancer. Cancer Chemotherapy and Pharmacology. ,vol. 25, pp. 299- 303 ,(1990) , 10.1007/BF00684890
Francis Lévi, Jean-Louis Misset, Silvano Brienza, René Adam, Gérard Metzger, Moshe Itzakhi, Jean-Pierre Caussanel, Francis Kunstlinger, Sylvie Lecouturier, Adrien Descorps-Declère, Claude Jasmin, Henri Bismuth, Alain Reinberg, A chronopharmacologic phase II clinical trial with 5-fluorouracil, folinic acid, and oxaliplatin using an ambulatory multichannel programmable pump. High antitumor effectiveness against metastatic colorectal cancer. Cancer. ,vol. 69, pp. 893- 900 ,(1992) , 10.1002/1097-0142(19920215)69:4<893::AID-CNCR2820690410>3.0.CO;2-X