Titin as a modular spring: emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology.
作者： Henk Granzier , Dietmar Labeit , Yiming Wu , Siegfried Labeit
DOI: 10.1007/978-94-010-0147-2_7
关键词: Molecular spring 、 Chemistry 、 Obscurin 、 Biophysics 、 Elasticity (economics) 、 Titin 、 Muscle stiffness 、 Muscle contraction 、 Cardiovascular physiology 、 Anatomy
摘要: Titin is a giant elastic protein that functions as molecular spring develops passive muscle stiffness. Here we discuss the basis of titin’s extensibility, how contribution to stiffness may be adjusted and adjustment influence contraction. We also focus on ligands link titin membrane channel activity, turnover gene expression.
springer.com
elsevier.com
sci-hub.st 参考文章(75)
Miklós S. Z. Kellermayer, Steven Smith, Carlos Bustamante, Henk L. Granzier, Mechanical manipulation of single titin molecules with laser tweezers. Advances in Experimental Medicine and Biology. ,vol. 481, pp. 111- 128 ,(2000) , 10.1007/978-1-4615-4267-4_7
Henk Granzier, Michiel Helmes, Olivier Cazorla, Mark McNabb, Dietmar Labeit, Yiming Wu, Rob Yamasaki, Alka Redkar, Miklós Kellermayer, Siegfried Labeit, Karoly Trombitás, Mechanical properties of titin isoforms. Advances in Experimental Medicine and Biology. ,vol. 481, pp. 283- 304 ,(2000) , 10.1007/978-1-4615-4267-4_17
Noriko Toyama-Sorimachi, Hiroyuki Sorimachi, Yoshimi Tobita, Fujiko Kitamura, Hideo Yagita, Koichi Suzuki, Masayuki Miyasaka, A Novel Ligand for CD44 Is Serglycin, a Hematopoietic Cell Lineage-specific Proteoglycan Journal of Biological Chemistry. ,vol. 270, pp. 7437- 7444 ,(1995) , 10.1074/JBC.270.13.7437
H C Hartzell, D B Glass, Phosphorylation of purified cardiac muscle C-protein by purified cAMP-dependent and endogenous Ca2+-calmodulin-dependent protein kinases. Journal of Biological Chemistry. ,vol. 259, pp. 15587- 15596 ,(1984) , 10.1016/S0021-9258(17)42588-9
Piotr E. Marszalek, Hui Lu, Hongbin Li, Mariano Carrion-Vazquez, Andres F. Oberhauser, Klaus Schulten, Julio M. Fernandez, Mechanical unfolding intermediates in titin modules. Nature. ,vol. 402, pp. 100- 103 ,(1999) , 10.1038/47083
M. Pfuhl, S.J. Winder, A. Pastore, Nebulin, a helical actin binding protein The EMBO Journal. ,vol. 13, pp. 1782- 1789 ,(1994) , 10.1002/J.1460-2075.1994.TB06446.X
Olga Mayans, Peter F. M. van der Ven, Matthias Wilm, Alexander Mues, Paul Young, Dieter O. Fürst, Matthias Wilmanns, Mathias Gautel, Structural basis for activation of the titin kinase domain during myofibrillogenesis Nature. ,vol. 395, pp. 863- 869 ,(1998) , 10.1038/27603
M P Williamson, The structure and function of proline-rich regions in proteins. Biochemical Journal. ,vol. 297, pp. 249- 260 ,(1994) , 10.1042/BJ2970249
Koscak Maruyama, Connectin/titin, giant elastic protein of muscle. The FASEB Journal. ,vol. 11, pp. 341- 345 ,(1997) , 10.1096/FASEBJ.11.5.9141500
Stefan Hein, Dimitri Scholz, Noboru Fujitani, Holger Rennollet, Thomas Brand, Andrea Friedl, Jutta Schaper, Altered Expression of Titin and Contractile Proteins in Failing Human Myocardium Journal of Molecular and Cellular Cardiology. ,vol. 26, pp. 1291- 1306 ,(1994) , 10.1006/JMCC.1994.1148