Probiotic yeast Kluyveromyces marxianus CIDCA 8154 shows anti-inflammatory and anti-oxidative stress properties in in vivo models
作者： D.E. Romanin , S. Llopis , S. Genovés , P. Martorell , V.D. Ramón
DOI: 10.3920/BM2015.0066
关键词: Reactive oxygen species 、 Microbiology 、 Probiotic 、 Oxidative stress 、 Kluyveromyces 、 Intestinal mucosa 、 In vivo 、 Anti-inflammatory 、 Kluyveromyces marxianus 、 Biology
摘要: Inflammatory bowel diseases (IBDs) are complex affections with increasing incidence worldwide. Multiple factors involved in the development and maintenance of symptoms including enhanced oxidative stress intestinal mucosa. The conventional therapeutic approaches for IBDs based on use anti-inflammatory drugs important collateral effects partial efficacy. In present work we tested capacity Kluyveromyces marxianus CIDCA 8154 different models. vitro, showed that pretreatment epithelial cells yeast reduce levels intracellular reactive oxygen species. Furthermore, a murine model trinitro benzene sulfonic acid-induced colitis, yeast-treated animals reduced histopathological score (P<0.05) lower circulating interleukin 6 (P<0.05). to modulate vivo was assessed using Caenorhabditis elegans model. able protect nematodes from by modulating SKN-1 transcription factor trough DAF-2 pathway. These results indicate K. could control inflammation cellular stress. Deciphering mechanisms action probiotics might be useful rational formulation polymicrobial products containing microorganisms targeting pathways.
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