Dual anticancer activity of 8-Cl-cAMP: inhibition of cell proliferation and induction of apoptotic cell death.
作者： Se Nyun Kim , Sang Gyun Kim , Jin Hyun Park , Myung Ae Lee , Sang Dai Park
关键词: Cell growth 、 Cell biology 、 8 cl camp 、 Chemistry 、 Human cancer 、 Apoptotic cell death 、 Neuroblastoma cell 、 Apoptosis 、 Growth inhibition 、 Significant difference
摘要: Abstract 8-Cl-cAMP induces apoptotic cell death in human cancer cells. To look at this more closely, we examined the changes levels of Bcl-2 family proteins during 8-Cl-cAMP-induced apoptosis SH-SY5Y neuroblastoma Following treatment with 8-Cl-cAMP, was transiently down-regulated and Bad increased continuously up to day 5. In addition, overexpression efficiently blocked apoptosis, suggesting may be involved apoptosis. The contribution inhibition proliferation growth closely monitored Bcl-2-overexpressing Though reduced significantly, no significant difference observed 2 treatment. These results suggest that exerts anticancer activity by two distinct mechanisms, i.e., through as well induction Supporting notion observations (1) suppression zVAD did not abrogate proliferation, (2) show additive RIIβ-overexpressing
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