Overexpression of HOXB3 in Hematopoietic Cells Causes Defective Lymphoid Development and Progressive Myeloproliferation

摘要: Abstract HOXB3 mRNA levels are high in the earliest CD34 + lineage − bone marrow cells and low to undetectable later /CD34 cells. To gain some insight into role this gene may play hematopoiesis, was overexpressed murine using retroviral transfer. Thymi of recipients were reduced size compared with control transplant recipients, a 24-fold decrease absolute number CD4 CD8 3-fold increase thymocytes that contained proportion γδ TCR B cell differentiation also perturbed these mice, as indicated by virtual absence transduced IL-7-responsive pre-B clonogenic progenitors. Recipients -transduced had elevated numbers mature granulocyte macrophage colony-forming their spleen. Together results suggest roles for proliferation processes both early myeloid lymphoid developmental pathways.