Dysregulation of Epidermal Growth Factor Receptor Expression in Premalignant Lesions during Head and Neck Tumorigenesis

摘要: Abstract The development of head and neck cancer, believed to result from field cancerization a multistep process tumorigenesis, is often associated with an accumulation genotypic phenotypic alterations. changes could be the dysregulation growth control genes such as epidermal factor receptor (EGFR). With goal identifying potential biomarker we studied specimens 36 squamous cell carcinomas 5 different sites that contained normal epithelia and/or premalignant lesions adjacent tumors. Almost all individuals whom these were obtained had been exposed first-hand smoking alcohol consumption. Using monoclonal anti-EGFR antibody for immunohistochemical analysis on paraffin-embedded sections attached 886 cells internal control, levels EGFR expression assessed by image analysis. relative staining intensity in tumors was 2-fold higher than epithelium (P = 0.021), suggesting that, even histologically epithelium, already up-regulated tissues surrounding These findings supported theory tumorigenesis. As tissue progressed tumor hyperplasia dysplasia, remained elevated. However, step dysplasia carcinoma, further dramatically 0.01). Therefore, results indicate happens two steps, moderate up-regulation change carcinoma. In summary, studies presented here might useful marker at risk intermediate end point chemoprevention trials.