Reduction of trapping of aggregated human igg in germinal centers by mitogens.

摘要: The effect of nonspecific mitogens on the trapping 125I-labeled aggregated human IgG (125I-AHGG) in germinal centers (GC) mouse spleens has been investigated by both radioactivity uptake and immunofluorescence. Phytohemagglutinin concanavalin A (Con A) significantly decreased trapping. Lipopolysaccharide produced less inhibition, pokeweed mitogen had no significant effect. maximum inhibition occurred with 250–500 μg Con A. This 125I-AHGG liver, kidney blood. No differences were found between i.p. i.v. routes injection. The GC is due more likely to modification migratory properties lymphocytes brought about surface binding, than their mitogenic properties, since localization thymectomized, x-irradiated bone marrow- reconstituted animals.