Increase in serum 25-hydroxyvitamin-D3 in humans after sunbed exposures compared to previtamin D3 synthesis in vitro
作者： Tetiana Orlova , Johan Moan , Zoya Lagunova , Lage Aksnes , Irina Terenetskaya
DOI: 10.1016/J.JPHOTOBIOL.2013.03.006
关键词: Calcifediol 、 Dosimetry 、 Ultraviolet 、 Stereochemistry 、 Cholecalciferol 、 In vivo 、 Skin cancer 、 Vitamin D and neurology 、 Previtamin D3 、 Endocrinology 、 Chemistry 、 Internal medicine
摘要: Ultraviolet (UV) radiation is liable to cause skin cancer but it the main source of vitamin D. Vitamin D photosynthesis takes place in at sub-erythemogenic UV doses, while larger exposures destroy and increase DNA damage. Proper dosimetry needed obtain an optimal status when risk minimal. A simple approach such using physically measured accumulated dose cannot provide a satisfactory quantification because complexity processes involved synthesis. biological dosimeter synthetic ('D-dosimeter') has been introduced earlier on basis vitro model previtamin photosynthesis. In present study vivo generation 25-hydroxyvitamin (25(OH)D) serum healthy volunteers exposed from sunbed was accompanied by measurements formation 'D-dosimeter'. It found that 25(OH)D concentration depended both initial level cumulative exposure time. The observed linear correlation between data can be used estimate changes after only one pre-exposure blood sample combined with further measurements.
elsevier.com
sci-hub.se 参考文章(24)
Nicholas J. Turro, Modern Molecular Photochemistry ,(1978)
Helmut Reichel, H. Phillip Koeffler, Anthony W. Norman, The role of the vitamin D endocrine system in health and disease. The New England Journal of Medicine. ,vol. 320, pp. 980- 991 ,(1989) , 10.1056/NEJM198904133201506
T. N. Orlova, I. P. Terenetskaya, UV-biosensor for visual indication of vitamin D synthesis Proceedings of SPIE, the International Society for Optical Engineering. ,vol. 7003, ,(2008) , 10.1117/12.780196
William B. Grant, Epidemiology of disease risks in relation to vitamin D insufficiency. Progress in Biophysics & Molecular Biology. ,vol. 92, pp. 65- 79 ,(2006) , 10.1016/J.PBIOMOLBIO.2006.02.013
Irina P. Terenetskaya, Duality of solar UV-B radiation and relevant dosimetry: vitamin D synthesis versus skin erythema Third International Asia-Pacific Environmental Remote Sensing Remote Sensing of the Atmosphere, Ocean, Environment, and Space. ,vol. 4896, pp. 144- 150 ,(2003) , 10.1117/12.466131
I Terenetskaya, Spectral monitoring of biologically active solar UVB radiation using an in vitro model of vitamin D synthesis Talanta. ,vol. 53, pp. 195- 203 ,(2000) , 10.1016/S0039-9140(00)00459-8
Zoya Lagunova, Emanuela Cicarma, Lage Aksnes, Arne Dahlback, William B. Grant, Alina Carmen Porojnicu, Johan Moan, Sunbeds as Vitamin D Sources Photochemistry and Photobiology. ,vol. 85, pp. 1474- 1479 ,(2009) , 10.1111/J.1751-1097.2009.00607.X
Alina Carmen Porojnicu, Øyvind Sverre Bruland, Lage Aksnes, William B. Grant, Johan Moan, Sun beds and cod liver oil as vitamin D sources Journal of Photochemistry and Photobiology B-biology. ,vol. 91, pp. 125- 131 ,(2008) , 10.1016/J.JPHOTOBIOL.2008.02.007
Mary Norval, Lars Olof Björn, Frank R. de Gruijl, Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct? Photochemical and Photobiological Sciences. ,vol. 9, pp. 11- 17 ,(2010) , 10.1039/B9PP00012G
Lill Tove N. Nilsen, Merete Hannevik, Tommy N. Aalerud, Bjørn Johnsen, Eva G. Friberg, Marit B. Veierød, Trends in UV irradiance of tanning devices in Norway: 1983-2005. Photochemistry and Photobiology. ,vol. 84, pp. 1100- 1108 ,(2008) , 10.1111/J.1751-1097.2008.00330.X