Biome engineering-2020.

作者: Harald Brüssow

DOI: 10.1111/1751-7915.12391

关键词: Gut microbiomeBiotechnologyBiomeGut floraDysbiosisGastrointestinal MicrobiomeBiologyComplex ecosystem

摘要: The gut microbiome research is going from a descriptive into an intervention phase. To optimize beneficial microbe-host interaction, we need to understand how steer the system by modulating nutrient input with which literally fed (e.g. diets, fibres, prebiotics, human milk oligosaccharides), and must learn modulate composition of microbiota adding microbes probiotics, faecal transplants) eliminating disturbing microbial members using, for example, bacteriophages in this highly complex ecosystem. current status field reviewed together outlook what might be expected until 2020, highlighting obstacles progress possible solutions these problems.

参考文章(78)
Noortje G Rossen, John K MacDonald, Elisabeth M de Vries, Geert R D'Haens, Willem M de Vos, Erwin G Zoetendal, Cyriel Y Ponsioen, Fecal microbiota transplantation as novel therapy in gastroenterology: A systematic review World Journal of Gastroenterology. ,vol. 21, pp. 5359- 5371 ,(2015) , 10.3748/WJG.V21.I17.5359
Harald Brüssow, What is health Microbial Biotechnology. ,vol. 6, pp. 341- 348 ,(2013) , 10.1111/1751-7915.12063
Guy C.J. Abell, Caroline M. Cooke, Corinna N. Bennett, Michael A. Conlon, Alexandra L. McOrist, Phylotypes related to Ruminococcus bromii are abundant in the large bowel of humans and increase in response to a diet high in resistant starch FEMS Microbiology Ecology. ,vol. 66, pp. 505- 515 ,(2008) , 10.1111/J.1574-6941.2008.00527.X
Suchita Panda, Ismail El khader, Francesc Casellas, Josefa López Vivancos, Montserrat García Cors, Alba Santiago, Silvia Cuenca, Francisco Guarner, Chaysavanh Manichanh, Short-Term Effect of Antibiotics on Human Gut Microbiota PLoS ONE. ,vol. 9, pp. e95476- ,(2014) , 10.1371/JOURNAL.PONE.0095476
Gary D Wu, Jun Chen, Christian Hoffmann, Kyle Bittinger, Ying-Yu Chen, Sue A Keilbaugh, Meenakshi Bewtra, Dan Knights, William A Walters, Rob Knight, Rohini Sinha, Erin Gilroy, Kernika Gupta, Robert Baldassano, Lisa Nessel, Hongzhe Li, Frederic D Bushman, James D Lewis, Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes Science. ,vol. 334, pp. 105- 108 ,(2011) , 10.1126/SCIENCE.1208344
Dinesh Vyas, Fecal transplant policy and legislation World Journal of Gastroenterology. ,vol. 21, pp. 6- 11 ,(2015) , 10.3748/WJG.V21.I1.6
Matthew J. Hamilton, Alexa R. Weingarden, Tatsuya Unno, Alexander Khoruts, Michael J. Sadowsky, High-throughput DNA sequence analysis reveals stable engraftment of gut microbiota following transplantation of previously frozen fecal bacteria Gut Microbes. ,vol. 4, pp. 125- 135 ,(2013) , 10.4161/GMIC.23571
Bojana Bogovič Matijašić, Tanja Obermajer, Luka Lipoglavšek, Iztok Grabnar, Gorazd Avguštin, Irena Rogelj, Association of dietary type with fecal microbiota in vegetarians and omnivores in Slovenia European Journal of Nutrition. ,vol. 53, pp. 1051- 1064 ,(2014) , 10.1007/S00394-013-0607-6
Harald Brüssow, Bacteriophage–host interaction: from splendid isolation into a messy reality Current Opinion in Microbiology. ,vol. 16, pp. 500- 506 ,(2013) , 10.1016/J.MIB.2013.04.007
M. J. Claesson, S. Cusack, O. O'Sullivan, R. Greene-Diniz, H. de Weerd, E. Flannery, J. R. Marchesi, D. Falush, T. Dinan, G. Fitzgerald, C. Stanton, D. van Sinderen, M. O'Connor, N. Harnedy, K. O'Connor, C. Henry, D. O'Mahony, A. P. Fitzgerald, F. Shanahan, C. Twomey, C. Hill, R. P. Ross, P. W. O'Toole, Composition, variability, and temporal stability of the intestinal microbiota of the elderly Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 4586- 4591 ,(2011) , 10.1073/PNAS.1000097107