Current Clinical Role of Genetic Profiling in Breast Cancer
作者： Ruta Rao , Mashrafi Ahmed , William T Leslie , None
关键词: Internal medicine 、 Oncology 、 Medicine 、 DNA profiling 、 MammaPrint 、 Chemotherapy 、 Microarray 、 Recurrence score 、 Disease 、 Breast cancer 、 Gene signature
摘要: Genetic profiling of breast cancer is emerging as an important prognostic and predictive tool, especially for patients with early-stage cancer. Several genetic profile assays are already commercially available, others being developed tested. OncotypeDx, a 21-gene assay, MammaPrint, 70-gene assay the most extensively evaluated tests. Currently, three prospective trials to assess value gene signature in certain subgroups ongoing. These Trial Assigning Individualized Options Treatment (Rx) (TAILORx) trial, endocrine-responsive (RxPONDER) trial recurrence score Microarray In Node-negative Disease may Avoid ChemoTherapy (MINDACT) using signature.
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