Combined use of genomic prognostic and treatment response predictors in breast cancer

摘要: 527 Background: An advantage of gene expression profiling-based diagnostic tests is that several different predictors can be applied to the same data and prognostic, as well endocrine- chemotherapy-sensitivity predictions generated from a single specimen. We tested this concept on two cohorts breast cancers including total 427 cases. Methods: Gene profiling results with Affymetrix U133A chips were available 198 stage I-II, lymph node-negative patients who received no systemic adjuvant therapy 229 I-III, HER-2 normal all preoperative paclitaxel/FAC chemotherapy. Genomic Grade prognostic index (GGI) 2 separate predictive signatures 200-gene endocrine sensitivity 207-gene clinical phenotype-specific chemotherapy response predictor each case. MammaPrint prediction also The accuracies these ...