Chapter 16 Hedgehog Signaling Pathway Inhibitors as Cancer Therapeutics

摘要: Publisher Summary This chapter describes the mechanism of action Hedgehog (Hh) inhibitors. The Hh pathway directs development multiple tissues during embryonic and contributes to tissue homeostasis in adults. inactivation causes birth defects, whereas abnormal activation is linked tumorigenesis several cancers. Genetic validation this human tumors comes from observations that patients with a germ line mutation Patched (Ptch1)—a component pathway—have activated signaling develop Gorlin syndrome, also known as “nevoid basal cell carcinoma (BCC).” In addition, aberrant without implicated number additional tumor types, including small lung cancer, gut-related tumors, pancreatic prostate cancer. inhibition either cells directly or non-malignant stromal cells, which part microenvironment support growth, has emerged an attractive target anticancer therapy.