Ambient temperature modulation of fenfluramine-induced thermogenesis in the rat.

摘要: Abstract The anti-obesity drug fenfluramine, promotes loss of weight by reducing food intake; however, there is controversy as to whether the can also elevate expenditure energy. Resting consumption oxygen (VO2) was measured in conscious rats determine injection fenfluramine increased metabolic rate and prior fasting, or ambient temperature altered response. Regardless were fed had been fasted for 22 hr, a thermoneutral environment (28°C), intraperitoneal dl-fenfluramine (20 mg/kg) caused raised consumption. This elevation sustained end 60-min period measurement after injection, at which point colonic found be increased. response largely attentuated when administered 23°C, decreased 60 min injection. At 4°C, inhibited thermogenesis against cold, fell exhibited hypothermia. It concluded that increase rate, but this effect not conditional on associated intake, has reported. Rather, governs stimulation inhibition will evoked. These effects explain, part, its divergent body temperature, reported previously.