Effects of high fat-feeding to rats on the interrelationship of body weight, plasma insulin, and fatty acyl-coenzyme a esters in liver and skeletal muscle

摘要: Rats fed a high-saturated fat diet consumed more energy, gained weight, and displayed hyperinsulinemia (P less than .05) without an elevation in the fasting plasma glucose level, compared with animals on two different high-carbohydrate diets. The total fatty acyl-coenzyme A (CoA) concentration was 18% .0001) 46% higher liver skeletal muscle, respectively, from rats high-fat each of other groups. Major long-chain acyl-CoA molecular species both tissues high fat-fed reflected acid profile diet. Approximately 29%, 21%, 16% muscle acyl-CoAs were comprised oleoyl-CoA, palmitoyl-CoA, stearoyl-CoA, respectively. amounts these three esters significantly after feeding treatments .0001). In contrast, linoleoyl-CoA lower diet, insulin levels correlated gain body weight or (r = .80, P .001 for weight; r .73, weight). Total ester content also strongly liver; .78, muscle).(ABSTRACT TRUNCATED AT 250 WORDS)