E2A-Pbx1 induces growth, blocks differentiation, and interacts with other homeodomain proteins regulating normal differentiation.
作者： M. P. Kamps
DOI: 10.1007/978-3-642-60479-9_2
关键词: Effector 、 Biology 、 Cellular differentiation 、 DNA-binding protein 、 B cell 、 Homeobox 、 Cell 、 Fusion protein 、 Progenitor cell 、 Cell biology 、 Molecular biology
摘要: Arrested differentiation is a hallmark of progenitor cell leukemias as well many other types human cancer. It hypothesized that such cancers express oncoproteins block differentiation. The E2A-Pbx1 oncoprotein results from the t(1;19) chromosomal translocation childhood pre-B acute lymphoblastic leukemia (pre-B ALL) fascinating because it blocks and physically interacts with homeodomain proteins, which are effectors normal These properties suggest attractive hypothesis by interfering ability proteins to orchestrate terminal B
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