Congenital cytomegalovirus infection is associated with high maternal socio-economic status and corresponding low maternal cytomegalovirus seropositivity.

摘要: Aims Human cytomegalovirus (CMV) is the leading infectious cause of congenital infection in developed countries. Globally, CMV seropositivity has been associated with low socio-economic status (SES); however, Australian data are lacking. Therefore, we examined association between SES and seroprevalence children pregnant women. Methods Three groups were examined: 1, a prospective cohort aged 0–15 years (n = 220); 2, clinic-based sample women 778); 3, case series infants 219) symptomatic infection. was determined using postcode-based score from Bureau Statistics.Group 1 recruited endocrinology clinics follow-up at Prince Wales Hospital Children's Westmead. Group 2 Royal for Women. Congenitally infected identified through Paediatric Surveillance Unit. Results CMV among all 20% (95% confidence interval (CI) 15–25%), there no (P 0.58). Seroprevalence 57% (53–60%), higher rates lower < 0.001). More cases reported highest (55%) than lowest (9%) 0.001). Conclusions A marked gradient evident but not unselected children. These findings highlight importance community-wide approach to awareness potential hygienic measures reduce burden Australia.