Congenital cytomegalovirus infection in Israel: screening in different subpopulations.

摘要: Background: The incidence of congenital cytomegalovirus in Israel has never been determined, either general or relation to various population subgroups. We recently proved the utility newborn urine polymerase chain reaction as a screening tool for CMV. Objectives: To define CMV infection two different subpopulations, model entire Israel. Methods: Urine specimens were randomly collected from 2,000 newborns Shaare Zedek Medical Center, Jerusalem, and HaEmek Afula (1,000 each). These hospitals have many characteristic differences, presumably representing diverse subjected PCR positive validated by viral culture. Maternal seroprevalence was determined representative sample mothers each hospital. Epidemiologic characteristics extracted hospital records compared. Results: Center mostly Jewish (97.7%) urban (87.0%), compared that (49.2% 61.0%, respectively, P < 0.01). Nevertheless, similar: 81.5% 85%, respectively. Ten (1.0%) 4 (0.4%) newborns, found (not significant). Conclusions: combined study 0.7% (95% confidence interval 0.3-1.0%). If this rate is extrapolated Israel, then total 945 cases can be expected among 135,000 annual deliveries. A nationwide program should considered.