Circulating tumour cells and lung microvascular tumour cell retention in patients with metastatic breast and cervical cancer.

摘要: We have shown that in up to half of the patients with metastatic breast cancer (MBC), higher numbers circulating tumour cells (CTCs) are present central venous blood (CVB) compared peripheral (PVB), suggesting lungs might retain a substantial number CTCs. Here we report presence cell emboli (TCE) microvasculature three out eight MBC and one patient cervical carcinoma who had markedly elevated CTCs blood. All these suffered from symptomatic dyspnoea not easily attributable other causes. No TCE were observed five CTC counts low (<5/7.5 ml). To investigate whether derived CVB or PVB exhibit different transcriptional characteristics explain selective retention, paired samples 12 advanced subjected gene expression analysis 105 genes. significant differences observed. Together, data suggest potentially clinically relevant retention lung can occur subset cancer, which seems be transcriptionally non-selectively.