Genes controlling spread of breast cancer to lung "gang of 4".
作者： W. H. Elsawy , W. Holzgreve , R. Radpour , X. Y. Zhong , S. Hahn
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摘要: Cancer-related mortality is caused in a large part by the metastasis of primary tumor. Each cancer has particular way spreading cancerous cells. Recently, genetic and pharmacological analysis identified set genes, such as epidermal growth factor receptor ligand epiregulin (EREG), cyclooxygenase-2 (COX2) matrix metalloproteinases 1 2 (MMP-1 MMP-2) that have been found to be associated with breast lung. Inhibition EGFR COX2 could minimize lung clinical setting. In this review, we summarized current knowledge on EREG, COX2, MMP-1 MMP-2 tumor development metastasis.
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