Epiregulin
作者： Hitoshi Toyoda , Toshi Komurasaki , Daisuke Uchida , Yasuko Takayama , Toshiaki Isobe
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摘要: Epiregulin, a novel epidermal growth factor (EGF)-related regulating peptide, was purified from conditioned medium of the mouse fibroblast-derived tumor cell line NIH3T3/clone T7. It 46-amino-acid single chain polypeptide, and its amino acid sequence exhibited 24-50% identity with sequences other EGF-related factors. Epiregulin bifunctional regulatory properties: it inhibited several epithelial cells stimulated fibroblasts various types cells. bound to EGF receptors epidermoid carcinoma A431 much more weakly than did EGF, but nevertheless potent as mitogen for rat primary hepatocytes Balb/c 3T3 A31 fibroblasts. These findings suggest that epiregulin plays important roles in by binding ligands.
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