Astemizole Synergizes Calcitriol Antiproliferative Activity by Inhibiting CYP24A1 and Upregulating VDR: A Novel Approach for Breast Cancer Therapy
作者： Janice García-Quiroz , Rocío García-Becerra , David Barrera , Nancy Santos , Euclides Avila
DOI: 10.1371/JOURNAL.PONE.0045063
关键词: Cell growth 、 Breast cancer 、 CYP24A1 、 Calcitriol receptor 、 Astemizole 、 Downregulation and upregulation 、 Calcitriol 、 Pharmacology 、 Chemistry 、 Carcinogenesis 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Background Calcitriol antiproliferative effects include inhibition of the oncogenic ether-a-go-go-1 potassium channel (Eag1) expression, which is necessary for cell cycle progression and tumorigenesis. Astemizole, a new promising antineoplastic drug, targets Eag1 by blocking ion currents. Herein, we characterized interaction between calcitriol astemizole as well their conjoint action in SUM-229PE, T-47D primary tumor-derived breast cancer cells.
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