Clinical Implications of the Pharmacokinetics of Tricyclic Antidepressants

作者: J. C. Nelson , C. Mazure , P. I. Jatlow

DOI: 10.1007/978-3-642-74430-3_24

关键词: PsychotherapistTricyclic antidepressant drugsTricyclicClinical PracticeHealthy subjectsPharmacokineticsMedicine

摘要: Knowledge gained during the past 20 years about pharmacokinetics of tricyclic antidepressant drugs has helped to refine clinical practice. This discussion will focus on kinetic features antidepressants which appear have important implications for

参考文章(41)
Zucker Dk, Livingston Rl, Isenberg K, Wetzel Rd, Tricyclic antidepressants and delirium. The Journal of Clinical Psychiatry. ,vol. 44, pp. 173- ,(1983)
S. Dawling, S. Ford, D. C. Rangedara, R. R. Lewis, Amitriptyline Dosage Prediction in Elderly Patients from Plasma Concentration at 24 Hours after a Single 100mg Dose Clinical Pharmacokinectics. ,vol. 9, pp. 261- 266 ,(1984) , 10.2165/00003088-198409030-00007
J Craig Nelson, Jay L Bock, Peter I Jatlow, Clinical implications of 2‐hydroxydesipramine plasma concentrations Clinical Pharmacology & Therapeutics. ,vol. 33, pp. 183- 189 ,(1983) , 10.1038/CLPT.1983.28
J Craig Nelson, Carolyn Mazure, Pater I Jatlow, Antidepressant activity of 2-hydroxydesipramine Clinical Pharmacology and Therapeutics. ,vol. 44, pp. 283- 288 ,(1988) , 10.1038/CLPT.1988.151
Frederic M. Quitkin, Duration of Antidepressant Drug Treatment Archives of General Psychiatry. ,vol. 41, pp. 238- 245 ,(1984) , 10.1001/ARCHPSYC.1984.01790140028003
U. Breyer-Pfaff, H. J. Gaertner, F. Kreuter, G. Scharek, M. Brinkschulte, R. Wiatr, Antidepressive effect and pharmacokinetics of amitriptyline with consideration of unbound drug and 10-hydroxynortriptyline plasma levels. Psychopharmacology. ,vol. 76, pp. 240- 244 ,(1982) , 10.1007/BF00432553
Robert G Cooke, Jerry J Warsh, Harvey C Stancer, Kenton L Reed, Emmanuel Persad, The nonlinear kinetics of desipramine and 2-hydroxydesipramine in plasma. Clinical Pharmacology & Therapeutics. ,vol. 36, pp. 343- 349 ,(1984) , 10.1038/CLPT.1984.185
Isamu Kitanaka, Richard J Ross, Neal R Cutler, Anthony P Zavadil, William Z Potter, Altered hydroxydesipramine concentrations in elderly depressed patients Clinical Pharmacology & Therapeutics. ,vol. 31, pp. 51- 55 ,(1982) , 10.1038/CLPT.1982.8
S. P. Kutcher, K. Reid, J. D. Dubbin, K. I. Shulman, Electrocardiogram Changes and Therapeutic Desipramine and 2-.Hydroxy-Desipramine Concentrations in Elderly Depressives British Journal of Psychiatry. ,vol. 148, pp. 676- 679 ,(1986) , 10.1192/BJP.148.6.676
Denis P. Eustace, Lithium-induced reaction. British Journal of Psychiatry. ,vol. 148, pp. 752- 752 ,(1986) , 10.1192/BJP.148.6.752A