Bioactive and immunoreactive FSH in serum of normal and oligospermic men.
作者： B. C. J. M. FAUSER , J. W. BOGERS , W. C. J. HOP , F. H. JONG
DOI: 10.1111/J.1365-2265.1990.TB00883.X
关键词: Blood plasma 、 Testosterone 、 Endocrinology 、 Internal medicine 、 Oligospermia 、 Biology 、 Granulosa cell 、 Gonadotropin 、 Azoospermia 、 Spermatogenesis 、 Leydig cell
摘要: In men suffering from idiopathic oligospermia and azoospermia the hypothesis was tested that decreased spermatozoa production could be due in part to inadequate hormonal stimulation of spermatogenesis. 53 healthy male subjects with normal (n = 10), varying degrees 40), 3), serum immunoreactive LH, testosterone (T), oestradiol (E2), bioactive FSH concentrations were determined. bioactivity estimated using rat granulosa cell aromatase bioassay. Mean T, E2 levels similar control group (spermatozoa concentration greater than 40 x 10(6)/ml) compared exhibiting mild (10-20 10(6)/ml), moderate (5-10 or severe (1-5 group. An inverse correlation found between (P less 0.05), elevated (twofold increase) combined 0.01) groups. Moreover, augmented also observed this patients. The mean ratio negatively correlated sperm counts 0.005). addition, T/LH ratios inversely 0.05) FSH, which may indicate altered Leydig function is involved secretion FSH. data presented study as measured azoospermia, does not exhibit bioactivity.
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