Harnessing the master transcriptional repressor REST to reciprocally regulate neurogenesis
作者： Edmund Nesti
DOI: 10.1080/23262133.2015.1055419
关键词: RE1-silencing transcription factor 、 PIN1 、 Neurogenesis 、 Gene silencing 、 Neuroscience 、 Regulatory site 、 MAPK/ERK pathway 、 Growth factor 、 Repressor 、 Biology
摘要: Neurogenesis begins in embryonic development and continues at a reduced rate into adulthood vertebrate species, yet the signaling cascades regulating this process remain poorly understood. Plasma membrane-initiated regulate neurogenesis via downstream pathways including components of transcriptional machinery. A nuclear factor that temporally regulates by repressing neuronal differentiation is repressor element 1 (RE1) silencing transcription (REST) factor. We have recently discovered regulatory site on REST serves as molecular switch for differentiation. Specifically, C-terminal domain small phosphatase 1, CTDSP1, present non-neuronal cells, maintains activity dephosphorylating site. Reciprocally, extracellular signal-regulated kinase, ERK, activated growth neural progenitors, peptidylprolyl cis/trans isomerase Pin1, decrease through phosphorylation-dependent degradation. Our findings fur...
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