Cottontail rabbit papillomavirus (CRPV) model system to test antiviral and immunotherapeutic strategies.

摘要: The cottontail rabbit papillomavirus (CRPV)/rabbit model has proven to be the most versatile preclinical test antiviral, immunopotentiating and immunotherapeutic strategies for papilloma-virus infections. We have utilized this many years recently observed significant improvements in utility of model. Improvements included various techniques infect skin sites with strains wild-type mutant CRPV DNA prepared using standard molecular biological procedures. A better understanding virus life cycle vivo been gained also from these studies such that we now several defined including i) antigenically diverse CRPV, ii) reduced growth rates, iii) demonstrate accelerated malignant progression rates. Collectively, genomes provide laboratories a powerful pre-clinical assess variety antiviral therapies. Many treatments already tested CRPV/rabbit shown parallel efficacy against HPV infections clinical setting. Some our recent experiences are outlined brief overview.