A retrospective cohort study of pancreatic neuroendocrine tumors at single institution over 15 years: New proposal for low- and high-grade groups, validation of a nomogram for prognosis, and novel follow-up strategy for liver metastases

作者: Liangtao Ye , Huilin Ye , Quanbo Zhou , Zhihua Li , Qing Lin

DOI: 10.1016/J.IJSU.2016.03.036

关键词: Univariate analysisMitotic indexNomogramMultivariate analysisSurgeryNeuroendocrine tumorsStage (cooking)MedicineInternal medicineRetrospective cohort studyOncologyCohort

摘要: Abstract Purpose Pancreatic neuroendocrine tumors (PNETs) exhibit various tumor behaviors and symptoms that are difficult for physicians to stage predict prognosis. We assess prognostic factors combined with staging classifications optimal the models try improve follow-up strategy monitor liver metastases after surgery. Methods Patients PNETs treated at Sun Yat-sen Memorial Hospital between 2000 2015 were recruited. regrouped on basis of functional status mitotic rates. Nomograms values (AJCC, ENETS, WHO) constructed; accuracy nomograms quantified by C-index calibration plots. Results identified 78 patients pathological reports. Correlations OS in univariate analysis included nonfunctional ( P  = 0.002), CgA>200 ng/ml  = 0.014; >20%,  = 0.011; >20/10HPF,  = 0.039; 3–20/10HPF,  = 0.015;  = 0.007). Evaluating new proposed system, difference low- high-groups was statistically significant  = 0.001). The higher than premise ones (AJCC cohort, 0.605 v 0.576, 0.691, 0.603, Conclusion An model based rates correlates strongly survival. should return visits every 2 months first half years, 3 as followed until years

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