trans-10, cis-12 CLA promotes osteoblastogenesis via SMAD mediated mechanism in bone marrow mesenchymal stem cells
作者： Jonggun Kim , Yooheon Park , Yeonhwa Park
DOI: 10.1016/J.JFF.2014.04.006
关键词: Bioinformatics 、 Mesenchymal stem cell 、 Cell biology 、 Conjugated linoleic acid 、 Adipocyte 、 Osteoblast 、 Adipogenesis 、 Receptor 、 Chemistry 、 SMAD 、 Mothers against decapentaplegic
摘要: The inverse relationship between osteoblast and adipocyte differentiation in bone marrow mesenchymal stem cells has been linked to overall mass. It previously reported that conjugated linoleic acid (CLA) inhibits adipogenesis via a peroxisome-proliferator activated receptor-γ (PPARγ) mediated mechanism, while it increases osteoblastogenesis PPARγ-independent mechanism cells. This suggests potential implication of CLA on improving Thus the purpose this study was determine involvement regulation murine by focusing Mothers against decapentaplegic (MAD)-related family molecules 8 (SMAD8), one key regulators osteoblastogenesis. trans-10,cis-12 CLA, but not cis-9,trans-11, significantly increased SMAD8, inhibited independent inhibiting factors regulating osteoclastogenesis model. These suggest may help improve SMAD8 mechanism.
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