Drug Interactions of Metformin Involving Drug Transporter Proteins.
作者： Naina Mohamed Pakkir Maideen , Abdurazak Jumale , Rajkapoor Balasubramaniam
关键词: Metformin 、 Drug interaction 、 Pharmacology 、 Organic cation transport proteins 、 Prediabetes 、 Gestational diabetes 、 Drug 、 Type 2 Diabetes Mellitus 、 Medicine 、 Pharmacokinetics
摘要: Metformin is a most widely used medication all around the world to treat Type 2 diabetes mellitus. It also found be effective against various conditions including, Prediabetes, Gestational mellitus (GDM), Polycystic Ovarian Syndrome (PCOS), Obesity, Cancer, etc. cationic drug and it depends Organic Cation Transporters (OCTs) Multidrug Toxin Extruders (MATEs) mostly for its pharmacokinetics movement. The probability of interaction increases with number concomitant medications. This article focuses interactions metformin them are linked inhibition OCTs MATEs leading increased plasma concentrations subsequent elevation risk Associated Lactic Acidosis (MALA). By identifying drugs inhibiting MATEs, healthcare professionals can predict metformin.
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sci-hub.se 参考文章(44)
F Purchiaroni, B Annibale, G Galli, Metformin plus proton pump inhibitors therapy: the cobalamin deficiency challenge. European Review for Medical and Pharmacological Sciences. ,vol. 19, pp. 2501- 2502 ,(2015)
Tore Bjerregaard Stage, Kim Brøsen, Mette Marie Hougaard Christensen, None, A Comprehensive Review of Drug–Drug Interactions with Metformin Clinical Pharmacokinetics. ,vol. 54, pp. 811- 824 ,(2015) , 10.1007/S40262-015-0270-6
Barbara Grün, Michael K. Kiessling, Jürgen Burhenne, Klaus-Dieter Riedel, Johanna Weiss, Geraldine Rauch, Walter E. Haefeli, David Czock, Trimethoprim-metformin Interaction and Its Genetic Modulation by OCT2 and MATE1 Transporters British Journal of Clinical Pharmacology. ,vol. 76, pp. 787- 796 ,(2013) , 10.1111/BCP.12079
C.J. Bailey, Carol Wilcock, Caroline Day, Effect of metformin on glucose metabolism in the splanchnic bed. British Journal of Pharmacology. ,vol. 105, pp. 1009- 1013 ,(1992) , 10.1111/J.1476-5381.1992.TB09093.X
Nancy C. Sambol, Janie Chiang, Emil T. Lin, Anita M. Goodman, Chui Y. Liu, Leslie Z. Benet, Martin G. Cogan, Kidney Function and Age Are Both Predictors of Pharmacokinetics of Metformin The Journal of Clinical Pharmacology. ,vol. 35, pp. 1094- 1102 ,(1995) , 10.1002/J.1552-4604.1995.TB04033.X
Hideyuki Motohashi, Ken-ichi Inui, Organic Cation Transporter OCTs (SLC22) and MATEs (SLC47) in the Human Kidney The AAPS Journal. ,vol. 15, pp. 581- 588 ,(2013) , 10.1208/S12248-013-9465-7
Janna K Duong, Timothy J Furlong, Darren M Roberts, Garry G Graham, Jerry R Greenfield, Kenneth M Williams, Richard O Day, None, The Role of Metformin in Metformin-Associated Lactic Acidosis (MALA): Case Series and Formulation of a Model of Pathogenesis. Drug Safety. ,vol. 36, pp. 733- 746 ,(2013) , 10.1007/S40264-013-0038-6
Sumito Ito, Hiroyuki Kusuhara, Miyu Yokochi, Junko Toyoshima, Katsuhisa Inoue, Hiroaki Yuasa, Yuichi Sugiyama, Competitive Inhibition of the Luminal Efflux by Multidrug and Toxin Extrusions, but Not Basolateral Uptake by Organic Cation Transporter 2, Is the Likely Mechanism Underlying the Pharmacokinetic Drug-Drug Interactions Caused by Cimetidine in the Kidney Journal of Pharmacology and Experimental Therapeutics. ,vol. 340, pp. 393- 403 ,(2012) , 10.1124/JPET.111.184986
H Gómez Herrero, C De Arriba Villamor, M Buldain Parra, M Arraiza Sarasa, None, Nefrotoxicidad por contrastes yodados en estudios de tomografía computarizada a pacientes ambulatorios diabéticos en tratamiento con metformina Anales Del Sistema Sanitario De Navarra. ,vol. 36, pp. 197- 201 ,(2013) , 10.4321/S1137-66272013000200003
Jiangxia Ren, Yan Zhou, Guoqiang Zhang, Liting Zhou, Jing Zhao, Yuhui Wei, Xin’an Wu, Role of age-related decrease of renal organic cation transporter 2 in the effect of atenolol on renal excretion of metformin in rats European Journal of Drug Metabolism and Pharmacokinetics. ,vol. 40, pp. 349- 354 ,(2015) , 10.1007/S13318-014-0214-9